Light wheels should make a difference, and in theory is one of the best places to shed weight.
That said, I dropped about 300g-400g on a wheelset change once (stock straight gauge spokes, wtb ST rims, formula hubs, about 2400g, to onyx classic hubs with WAO Union rims). And honestly, I wouldn’t say it made a huge difference (the weight itself). Definitely not an earth shattering experience.
What did make a huge difference was my rims are no longer dinging/denting at all, and from 30poe, to infinite Poe. Maybe if I’d only changed the wheelset weight, instead of the hubs/Poe, I would have noticed it more. Or maybe it’s because the wheelset is still pretty heavy? Or because I’m riding more winch and plummet sorts of terrain, so I’m not accelerating out of corners on climbs all that often. It’s more of a steady climbing sort of thing.
Imo the reason to switch is to not have wheels that are denting all the time. My old wheelset would get a ding just looking at them funny (even running DD tires at 30psi). So the fact that my new rims are still perfectly straight 3 years later, is huge.