A couple of years ago I found that magic gear ration with one singlespeed project, 33:18 fit in a Cannondale Chase. Using a Truvative 33T chainring and a steel DX cog, a new SRAM PC-99 chain would fit REAL snug, but wear in fairly fast to a point where it would fit perfectly and not noticably change tension most of its remaining chain life until the end. I check my chains with a Rohloff chain wear tool. I replace them when they get to a point where the Rohloff tool indicates they are at thye end of their usefull life, and the chain was never loose enough to push off the chainring by hand on that bike. Got lucky I guess. Tried every other close or equivalent gear combo and either too loose or too tight.
I have discovered that the type of chainrings, cogs and chains can contribute to a slight amount of difference with that magic ratio, so nothing is for sure. I ran a Surly Singlator on one bike after that and am currently riding singlespeeds with horizontal drops and chain-tugs, but it is possible on some frames. Your best bet is to get an accurate measurement of the rear axle center to BB center (chainstay length), and type the numbers into a gear calculator. I used to use SingleSpeed gear Calculator, but it's no longer available. Would like to find another good one.
Cheers,
Dave