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I'm running 12sp SRAM Eagle and using a SRAM crank with a 49mm chainline on a 142 frame. It won't match...but you can use a SRAM GX crank and use a chaining with a 6mm offset if you're not sure of the Shimano offset.

I think Shimano specifies the same chainline for both non and Boost frames with the 8100 cranks.
 
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