Cadence aside
I guess if you are a disciplined cadence guy, they might have some negative impact, but in all honesty, how many of us are? I know I try, but when things get hairy I mash just like most dudes. Old habits are hard to break
Having BMX background, I always ran 180's on my 20" bike and 185- 190's on my 24" cruiser. The extra length gave me more leverage and snap out of the gate. My whole game was leg strength, and I could pull a taller gear with the long crank and still out accelerate most everyone. One I was up to speed the tall gear helped me pull away.
This was the days before BMX tracks became the obstacle courses they tend to be knowadays, so this set up served me well.
Im only 5'8" with a 30" inseam. If I had longer legs, I'd upgrade my MTB to longer cranks (I run 175's) For long MTB rides with alot of climb (not BMX sprints) I'd be worried about the impact that the increased overall stroke distance (top dead center to bottom dead center) might have on my aging and feeble knees! If I had long legs, I'd be all over it!
One old man's opinion! haha