Seriously.
TLDR - I think you'll be fine with the QR 141. QR141 will be more finicky when reseating the wheel than a thru-axle possibly creating some disc rub. This can be managed. Good news is if you buy new wheels, most boost 148 hubs can be converted to support QR141 with an end cap swap. So, you have an upgrade path if you desire. The only issue I see with QR is the failure mode if the QR skewer where to fail. However, this is not likely.
Now the too long part. Let's clear up some misconceptions.
The axle in the QR141 hub is not the 5 mm QR skewer. The axle in a thru-axle hub is not the thru-axle. Both the skewer and the thru axle slide thru the hub's axle.
It's possible that a QR hub uses a 10 mm axle which slots into the dropouts in the frame. This is how axles were made for a long time. The axle was longer than the OLD, the OLD is the frame spacing spec, in this case 141 mm. This was true until we got fancy hubs like hope, dt, i9, onyx etc. In those hubs - even before thru axles, the hub's axle is typically larger in diameter than the 10 mm of the frame interface to improve things like stiffness and strength, and possibly made of aluminum to reduce weight. In these hub designs the axle does not engage with the frame. The axle engages with end caps or bolts that then engage the frame.
Therefore, axle strength is not a matter of QR or Thru-axle. It's a matter of how the hub was designed. If you are concerned about this, then you need to fully understand the design of the hub in the bike you choose to purchase. Check out this thread if you doubt me.
(1) Love my i9 Hydra hubs, but the breakage is mounting | Mountain Bike Reviews Forum (mtbr.com)
The negative of a QR hub is mostly about consistent alignment. There is play between the frame and the hub, so it's possible when you reseat the wheel it will be aligned slightly different than it was before. With disc brakes this can mean you get some disc brake rub. Maybe this could affect shifting. I'm not sure on that one. I have two bikes with QR's and disc brakes. I manage alignment by making sure that the axle - or end caps - that interface with the frame, is all the way forward in both dropouts prior to engaging the QR or bolts.
The other issue with QR is failure mode. If the QR skewer were to snap or the QR fail, there is nothing holding the wheel in the frame (other than gravity). Funny story. I actually rode my bike once without the QR skewer in and didn't notice it. This was short shake out ride. I got back and saw the QR sitting there and thought W-T-F. I don't recommend this.
A thru-axle is also a single point of failure. If a thru-axle snaps, the remaining now two-or-more-piece thru-axle remains captured by the frame, one end is still threaded into the frame, the other end - on most thru axle designs - has a full loop that requires the new thru-axle segment to slide all the way out before the wheel will come out. So, unless you fully remove one end of the thru-axle the wheel cannot come out.
Note that for nutted hubs or some bolt on hubs like Hope, CK, Surely Ultra new disc there is no single point of failure. In these hubs you have two independent bolts. Each with its own threads into the axle holding the wheel in the frame. So, if one fails the other is still engaged. The Surely Ultra New rears also have wicked consistent alignment with the "washers" they provide in Ritchey style dropouts. The hope 10 mm bolts also are a true 10 mm's and have very little play in the dropout providing consistent alignment.