Nope. I drilled out my i23 last year and have about a year of use on them. So far, no problems.
I've been drilling out rims to Schrader for something like 20 years, I've never had a rim fail because I drilled it.
I drilled out both my i25 Freq rims. I have a drill press so it was super simple. Just keep that hole straight. I uses 949 brand schrader valves.
There is very little amount of material removed.
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