No 22.5mm is not too narrow for a 2.1" tyre, but wouldn't want anything skinnier, would limit what size tyres you can run (bigger) and be able to take advantage of lower pressures without tyre roll/squirm.
If you already have the wheels that size will work. If you're thinking of getting a new wheelset I'd consider wider, especially for a front where your fork can likely take a much wider than 2.1 tire. And see what the widest tire your frame will take. Don't just go with the size the bike came with. Measure the tire clearance between the chainstays and the seatstays. You can get by with less than the recommended 6mm if you have an aluminum frame. If you can fit a wider tire you can then think about which tire matches your terrain and speed to pick a rim size. You can get a big bump in performance if you can fit wider rims and tires at lower pressures in some terrains.
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