It depends on the frame. If it has(or was designed for) the press in SI headset cups then it can take 1.5 standard headsets, although I believe you may need something with a fairly short insertion depth. Some Cannondale frames were designed for a headset with fairly short (c. 10 mm) insertion into the frame, and some 1.5 headsets are designed for deeper insertion into the frame. the double xc was made in several sizes for this reason - a standard 20 mm deep, and a "short" 10mm deep headset. The double xc flush was 20mm deep but it looks like the new one on their website is shorter so that may be ok. If it comes with the integrated headset, then there is a reducer headset you can buy from cannondale. As far as frame clearance, I don't know. Offset is measured at the dropouts, so it doesn't really tell you anything. Maybe you can find someone who has used the same frame/fork combo?