here is what i would do with 2 weeks....start in the denver area by getting used to altitude and ride a day at something like buffalo creek, camp there, and then i would drive down to salida area for another day of adjusting and find a nice easy ride. day 3 - probably Agate creek on Monarch pass (easier than crest but very sweet). head to gunnison, camp at hartmans and ride there for day 4 (nothing steep, fun rolling terrain). day 5 and 6 and 7 in Crested Butte area - i would do reno-flag-bear, 403 and 401 in one day and Dr park in Taylor Canyon. I would then drive over to Fruita for at least 2 days there, take your pick of rides but i like marys, horsethief bench to steves to mack ridge and then one day on all the 18 road stuff.. then day 10 head up to breckenridge-frisco for Colorado trail-swan river ride. if you have more days add another on monarch and ride the crest trail..
temperature in the mountains will be 60's, maybe 70's during the day and 35-45 at night.. in fruita or front range add about 10 degrees or more...
there is a product out there call Acclimate that helps you adjust to high altitude, i have tried it and it seems to work well, you take it a week before you come out...also works real well for hangovers...its made by a doctor in Crested Butte...see if you can find it online, well worth it.
fun dreaming about what i would do with 2 weeks....Matchless mountain is another favorite of mine (taylor park between gunnison and Crestedd butte) have fun!!
might be able to be tour guide on monarch pass the weekend of sept 25 as we will be in salida for a wedding.