I haven't done that exact route, but have covered quite a bit of that territory on different rides. Do you plan on starting near Kelvin? There have been reports of vandalism at that AZT trailhead. Not sure what safer options are in that area. That said, picketpost is a bit more safe for parking and there will likely be a camp host there so I feel good parking there for several nights. There is a new-ish water collector right off the AZT (research it) that greatly helps with that grunt from the river to picketpost. At 2500 gallons (and full at last check, even in August) it is fairly reliable. Nothing is guaranteed of course...
Not sure where you are from, but it is rugged and it is a very backcountry experience. Expect limited cell coverage in spots. You need to be very self sufficient and able to repair mechanicals or be willing to walk 20 miles to self extract as vehicle access is limited. Given the most recent monsoon season, the trail is very overgrown in spots and even more rugged than usual. That said, I expect trail conditions to improve as it will be receiving more traffic now that the weather is good. The AZTR (just started today!) should help considerably.
Have fun, it's an absolutely magical place.