I've been running SRAM PC59 chains exclusively on my singlespeed-esq Speedhub, Nexus and Spectro drivetrains and haven't had a bit of trouble with the chains nor the Powerlinks. The catch is that, unless you're running a tensioner, you'll need to loosen your wheel to work the Powerlink. On the bike with sliding vertical dropouts, it's as easy as opening the QR and pulling the wheel out half-an-inch to get the required amount of slack, but on the bikes with the bolt-on hub and horizontal drops, it's a little more of a pain in the butt -- still easier that extracting pins, though.