The ISO is what you need to pay attention to when dealing with tire sizing.
Working in a shop you'll learn pretty quick.
Look on your current tires, you see what looks like a code. 26" MTB tire is 559 ISO, and the 559 is printed on most 26" mtb tires.
When dealing with tires you'll also learn that fractions and decimals do not transcend. 26"x 1 1/4 is WAY different than 26"x 1.25. The diameters are not the same.
I think we've got most things standardized, now.